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Dosage and half life Rats were sorted by weight, assigned to experimental groups (n = 5/group) and operated as described above. The experimental group consisted of oral administration of LGD3303 dosage(0.3-100 mg/kg/day) or osmotic minipump (Alzet model 2ML1; Alzet, Cupertino, CA; constant infusion of LGD3303; dose range of 0.01-10 mg/L Kg/day). Small pumps were surgically implanted into intradermal tissue, while rats underwent ORDX under anesthesia. Seven days later, the rats were anesthetized and a small pump was surgically removed and replaced with a new small pump. LGD3303 was formulated for oral administration as described above and formulated for micropump administration in 50% polyethylene glycol-400:50% dimethylsulfoxide. On the 14th day of the experiment, blood was collected into the lithium heparin tube (Becton Dickinson) by jugular puncture at 0, 0.5, 1, 2, 4, 8, 12 and 24 hours after administration. The blood was centrifuged and the plasma concentration of LGD3303 was measured. On the fifteenth day, the rats were sacrificed and the wet weights of the ventral prostate and levator ani muscles were measured. Cycle stack dosage DHT levels in the prostate may be higher than muscle or systemic circulation. It is conceivable that other SARMs and steroidal androgens have pharmacological characteristics that differ from those of LGD3303 due to the uneven tissue distribution and that similar evaluations of these compounds are required to perform a full comparison with it. In short, we have demonstrated that LGD3303 is a full agonist of muscles that are active on partial agonists of the prostate. Partial agonist activity is not a result of changes in saturation exposure, tissue-specific compound distribution, or normal circadian rhythms of androgen exposure. The tissue selectivity of LGD3303 may be the result of altered AR level interactions. Very promising SARM still in development. LGD3303 is a selective androgen receptor modulator (SARM) with im
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