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What are a drug substance intermediate and active pharmaceutical intermediates? A drug substance intermediate is a drug that is used as an API for the production of raw materials, and can also refer to raw materials that are produced during the synthesis of an API and must undergo further molecular changes or processing to become an API. Pharmaceutical intermediates are the compounds that make up the components of an active pharmaceutical ingredient (API). Pharmaceutical intermediates are produced as by-products in the production of APIs, and each reaction in the API production process produces a variety of different pharmaceutical intermediates. Active Pharmaceutical Ingredients (APIs) are the active ingredients in drugs that produce the effects on the body needed to treat disease. APIs are produced by processing compounds.
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